|
|
|
|
|
Click Here to return To Results
|
|
|
|
To identify those patients most likely to benefit from a cerebral biopsy to diagnose dementia,we reviewed a series of 14 unselected biopsies performed during a 9-year period(1980 through 1989)at Duke University Medical Center,Durham,NC.Pathognomonic features allowed a definitive diagnosis in seven specimens.Nondiagnostic abnormalities but not diagnostic neuropathologic changes were seen in five additional specimens, and two specimens were normal.Creutzfeldt-Jakob disease was the most frequent diagnosis.One patient each was diagnosed as having Alzheimer's disease,diffuse Lewy body disease,adult-onset Niemann-Pick disease,and anaplastic astrocytoma.We conclude that a substantial proportion of patients presenting clinically with atypical dementia are likely to receive a definitive diagnosis from a cerebral biopsy.However,in those with coexisting hemiparesis,chorea,athetosis,or lower motor neuron signs, cerebral biopsies are less likely to be diagnostic. |
|
(click to filter results - removes previous filter)
brain biopsy
brain biopsy,complications of
brain biopsy,false negative
brain biopsy,indication
dementia
dementia,diagnostic evaluation of
Jakob-Creutzfeldt disease
Lewy body disease,diffuse
lipid storage disorder of CNS
Niemann-Pick disease
|
Click Here to return To Results
|
|